UDC: 542.91.547.466.

Kodirov M.Z., Bobizoda G.M., Zafarov S.Z.

REVIEWER: Rajabov S.,

 Doctor of Chemical Sciences,

Professor

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MODIFICATION AND RESEARCH OF α, b, γ-AMINOIL ACIDS WITH FULLERENE C₆₀

In nature, there are amino acids that are not found in protein hydrolysates. These amino acids include α, b, γ-aminobutyric acids. α-Aminobutyric acid, which is formed in living organisms during the metabolism of proteins, is a non-proteinogenic alpha amino acid. In the human body, it is involved, for example, in the biosynthesis of ophthalmic acid. β-Aminobutyric acid is an isomer of aminobutyric acid, which is found in plants, where it can play a role in signaling. β-Aminobutyric acid is able to increase the resistance of plants to diseases and have a direct effect on pathogens of plant diseases, activates the immune system of plants. γ-Aminobutyric acid plays a crucial role in the transmission of nerve excitation. In order to maintain stability and increase the effect of aminobutyric acid isomers on living organisms and plants, we decided to attach C₆₀ fullerene to the NH₂ - aminobutyric acid group and obtain N-fullero C₆₀-aminobutyric acid for further study of biological properties. N-Fullero C₆₀-aminobutyric acid was synthesized using the thermal method of binding amino acids to C₆₀ fullerene. As is known, most amino compounds in the reaction with fullerene C₆₀ by the nucleophilic attachment mechanism can join at position 1.2 of the benzene ring of fullerene-C₆₀. Using this mechanism, 3 new compounds were synthesized: fullero C₆₀-α-aminobutanate, fullero C₆₀-b-aminobutanate, fullero C₆₀-γ-aminobutanate. The identity and purity of the obtained substances was checked by thin-layer chromatography and IR spectroscopy. Chromatographic data and melting points of the obtained substances confirm the formation of fullero-C₆₀-α-aminobutanate, fullero-C₆₀-b-aminobutanate and fullero-C₆₀-γ-aminobutanate.

Key words: fullerene-C₆₀, reaction, aminobutyric acid, thermal method, bromobenzene, dimethylformamide, spectrum, thin-layer chromatography.

Information about the authors: Kodirov Murod Zokirovich - Tajik National University, Candidate of Chemical Sciences, Associate Professor of Organic Chemistry Department.Address: 734025, Dushanbe, Republic of Tajikistan, Rudaki Avenue 17. Phone: 935983847. E‑mail: This email address is being protected from spambots. You need JavaScript enabled to view it..

Bobizoda Gulomkodir Mukkamal - Tajik National University, Doctor of Biological Sciences, Doctor of Pharmaceutical Sciences, Professor of Organic Chemistry Department. Address: 734025, Dushanbe, Republic of Tajikistan, Rudaki Ave., 17. Phone: +992-(918)-17-03-60. E- mail: This email address is being protected from spambots. You need JavaScript enabled to view it..

Zafarov Sorbon Zafarovich - Tajik National University, Candidate of Chemical Sciences, Senior Lecturer of Organic Chemistry Department. Address: 734025, Dushanbe, Republic of Tajikistan, Rudaki Ave., 17. Phone: +992-(937)-70-03-95. E-mail:This email address is being protected from spambots. You need JavaScript enabled to view it..

Article received 20.11.2023

Approved after review 24.02.2024

Accepted for publication 10.04.2024